Rheumatoid Arthritis

There is an association between periodontitis and the development of RA in patients who are susceptible.

Aggregatibacter actinomycetemcomitans can contribute to periodontitis by producing a toxin that can trigger hypercitrullination in neutrophils.

  • Hypercitrullination can trigger the formation of autoantibodies.
  • Treatment of periodontal disease in patients with RA has led to reductions in some markers of disease activity in RA patients (ESR, TNF-α titers, and disease activity scores).



Abbasi, J. To Prevent Rheumatoid Arthritis, Look Past the Joints to the Gums.  JAMA. 2017; 317(12): 1201-1202.

Kaur S, Bright R, Proudman SM, Bartold PM. Does periodontal treatment influence clinical and biochemical measures for rheumatoid arthritis? A systematic review and meta-analysis. Seminars in Arthritis and Rheumatism. 2014; 44(2): 113-122.