Dietary fluoride supplementation by prescription for children at high caries risk who do not have access to optimally fluoridated water is recommended by the American Academy of Pediatric Dentistry and the Centers for Disease Control and Prevention.
In 2021, the USPSTF recommended primary care clinicians prescribe oral fluoride supplementation starting at age 6 months for children whose water supply is deficient in fluoride, not based on risk assessment. The American Academy of Pediatrics also recommends fluoride supplements age 6 months to 16 years of age for children whose water supply is deficient in fluoride, not based on risk assessment.

American Academy of Pediatric Dentistry. Policy on use of fluoride. The Reference Manual of Pediatric Dentistry. Chicago, IL: American Academy of Pediatric Dentistry; 2025:110-2.
Clark MB, Keels MA, Slayton RL; AAP Section on Oral Health. Fluoride use in caries prevention in the primary care setting. SECTION ON ORAL HEALTH. Pediatrics. 2020; 146 (6).
U.S. Preventive Services Task Force Recommendation Statement. Prevention of Dental Caries in Children from Birth Through Age 5 Years. U.S. Preventive Services Task Force Recommendation Statement. Prevention of Dental Caries in Children Younger Than 5 Years: Screening and Interventions. December 07, 2021. View here.