White spots and lines are demineralized areas of enamel that represent the first clinical signs of caries.
Weyant, Robert J. et al. Topical Fluoride For Caries Prevention. JADA, 2013, Volume 144 (11): 1279-1291.
American Academy of Pediatric Dentistry. Policy on early childhood caries (ECC): Unique challenges and treatment options. The Reference Manual of Pediatric Dentistry. Chicago, Ill.: American Academy of Pediatric Dentistry; 2023: 92-3.