Prescribe oral or systemic antivirals if lesion is prodromal or early in its clinical course.
Reassurance is usually all that is required. Topical Orabase can be prescribed for pain control. Consider topical steroids if lesions are severe or protracted.
Simply observe unless interfering with eating or dental appliances.
Counsel to stop using tobacco products and refer to an oral surgeon for biopsy if present for longer than 2 weeks.