Silver Diamine Fluoride (SDF) is FDA approved as a desensitizing agent, but has "breakthrough therapy status" which facilitates its use in clinical trials. SDF may be indicated in older adults for caries management who have physical or cognitive limitations that prevent conventional restorative or invasive dental treatment (endodontics or extractions). SDF is a topical application which when applied every six months, arrests 91% of carious lesions within two years. The University of California San Francisco School of Dentistry has published a protocol for the use of SDF for caries management.
Tan HP, et al. A Randomized Trial on Root Caries Prevention in Elders. JDR 2010; 89(10);1086-1090.
Horst J. Silver Diamine Fluoride Use in older adults. Decisions in Dentistry. 2016; 2(08): 30-33.
Horst JA, Ellenikiotis H, Milgrom PM, et al. UCSF protocol for caries arrest using silver diamine fluoride: Rationale, indications, and consent. Journal of the California Dental Association. 2016; 44(1): 16-28.