The following table summarizes the current medical literature on this subject. At present, studies do not demonstrate that treatment of periodontal disease during pregnancy improves pregnancy outcomes. However, the studies do demonstrate that periodontitis improved with treatment and that treatment is safe during pregnancy. Studies are needed to determine if pre-pregnancy treatment would lower risk as treatment during pregnancy may be too late to avoid effects of inflammation or placental colonization.
|Polyzos et al, 2009||Metaanalysis of 7 RCTs||Case 1491 Control 1172||Tx produced: Lower PTB OR 0.55 (p=0.008) Lower LBW OR 0.48 (p=0.049)|
|Offenbacher et al, 2008||RTC||Case 903 Control 903||No difference in PTB, LBW|
|Srinivas et al, 2009||RTC||Case 311 Control 425||No difference in PTB, IUGR, Preeclampsia|
|Newnham et al, 2009||RTC||Case 542 Control 540||No difference in PTB|
|Cochrane 2017||Meta-analysis of 15 RCTs||7161 participants||No difference in PTB, Preeclampsia, or Perinatal Mortality; Lower LBW <2500g in subset of 7 studies, RR 0.67, 95% CI 0.48-0.95|
Definitions: PTB = Preterm Birth, LBW= Low Birth Weight, OR = Odds Ratio, CI=Confidence Intervals, RR = Relative Risk